Marcelo Sousa and Megan Mitchell at the University of Colorado Boulder are looking at a different approach against antibiotic resistance: targeting the resistance mechanism itself, controlled in this case with enzymes.
Using AlphaFold, (an AI system developed by Google DeepMind that predicts a protein’s 3D structure from its amino acid sequence) Marcelo and Megan explain how they solved the structure of one such enzyme – a challenge that a decade of experimentation couldn’t complete – in minutes.
Links and further reading:
Find more AlphaFold stories at https://dpmd.ai/3QcmjDj
Find out more about the Sousa Research Group at the University of Colorado Boulder https://www.colorado.edu/lab/sousa/
Find these complex enzymes on the AlphaFold Protein Structure Database https://dpmd.ai/3KcMEgX
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